I have always used cryptsy.. before I used BTC-e. But I went over to cryptsy because they have more coins etc.
The only thing I think is pretty dusturbing with cryptsy is that the deposits are really really slow sometimes. The withdrawals are faster than deposits (lol).
I've been waiting over an hour for a withdrawal of DRK from Cryptsy. The withdrawal is "confirmed" on my account page but hasn't hit the blockchain yet. This is painful!
My god, this is painful! Over two hours since Cryptsy confirmed my DRK withdrawal and it STILL hasn't hit the blockchain. Their chat mods have told me that this is not abnormal and that I shouldn't worry. I'm not actually worried about my coins...more worried about the time window that I have to work with!
Fiat on exchanges is always awkward. I usually withdraw it as Bitcoin and then exchange to fiat through different means (for me I have trusted buyers, but localbitcoins is a good way to make a bit of profit and you can get deposits to your bank account).